A propensity score-matched analysis of the impact of statin therapy on the outcomes of patients with non-small-cell lung cancer receiving anti-PD-1 monotherapy: a multicenter retrospective study.
In: BMC Cancer, Jg. 22 (2022-12-01), Heft 1, S. 1-20
Online
academicJournal
Zugriff:
Background: Many studies have recently reported the association of concomitant medications with the response and survival in patients with non-small-cell lung cancer (NSCLC) treated with cancer immunotherapy. However, the clinical impact of statin therapy on the outcome of cancer immunotherapy in patients with NSCLC is poorly understood. Methods: In our database, we retrospectively identified and enrolled 390 patients with advanced or recurrent NSCLC who were treated with anti-programmed cell death-1 (PD-1) monotherapy in clinical practice between January 2016 and December 2019 at 3 medical centers in Japan to examine the clinical impact of statin therapy on the survival of patients with NSCLC receiving anti-PD-1 monotherapy. A propensity score-matched analysis was conducted to minimize the bias arising from the patients' backgrounds. Results: The Kaplan-Meier curves of the propensity score-matched cohort showed that the overall survival (OS), but not the progression-free survival (PFS), was significantly longer in patients receiving statin therapy. However, a Cox regression analysis in the propensity score-matched cohort revealed that statin therapy was not an independent favorable prognostic factor, although it tended to be correlated with a favorable outcome. Conclusions: Statin therapy may be a combination tool for cancer immunotherapy in patients with NSCLC. These findings should be validated in further prospective studies with larger sample sizes. [ABSTRACT FROM AUTHOR]
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A propensity score-matched analysis of the impact of statin therapy on the outcomes of patients with non-small-cell lung cancer receiving anti-PD-1 monotherapy: a multicenter retrospective study.
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Autor/in / Beteiligte Person: | Takada, Kazuki ; Shimokawa, Mototsugu ; Takamori, Shinkichi ; Shimamatsu, Shinichiro ; Hirai, Fumihiko ; Tagawa, Tetsuzo ; Okamoto, Tatsuro ; Hamatake, Motoharu ; Tsuchiya-Kawano, Yuko ; Otsubo, Kohei ; Inoue, Koji ; Yoneshima, Yasuto ; Tanaka, Kentaro ; Okamoto, Isamu ; Nakanishi, Yoichi ; Mori, Masaki |
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Zeitschrift: | BMC Cancer, Jg. 22 (2022-12-01), Heft 1, S. 1-20 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 1471-2407 (print) |
DOI: | 10.1186/s12885-022-09385-8 |
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