Gender Differences in Takotsubo Syndrome.
In: Journal of the American College of Cardiology (JACC), Jg. 79 (2022-05-31), Heft 21, S. 2085-2093
Online
academicJournal
Zugriff:
Background: Male sex in takotsubo syndrome (TTS) has a low incidence and it is still not well characterized. Objectives: The aim of the present study is to describe TTS sex differences. Methods: TTS patients enrolled in the international multicenter GEIST (GErman Italian Spanish Takotsubo) registry were analyzed. Comparisons between sexes were performed within the overall cohort and using an adjusted analysis with 1:1 propensity score matching for age, comorbidities, and kind of trigger. Results: In total, 286 (11%) of 2,492 TTS patients were men. Male patients were younger (age 69 ± 13 years vs 71 ± 11 years; P = 0.005), with higher prevalence of comorbid conditions (diabetes mellitus 25% vs 19%; P = 0.01; pulmonary diseases 21% vs 15%; P = 0.006; malignancies 25% vs 13%; P < 0.001) and physical trigger (55 vs 32% P < 0.01). Propensity-score matching yielded 207 patients from each group. After 1:1 propensity matching, male patients had higher rates of cardiogenic shock and in-hospital mortality (16% vs 6% and 8% vs 3%, respectively; both P < 0.05). Long-term mortality rate was 4.3% per patient-year (men 10%, women 3.8%). Survival analysis showed higher mortality rate in men during the acute phase in both cohorts (overall: P < 0.001; matched: P = 0.001); mortality rate after 60 days was higher in men in the overall (P = 0.002) but not in the matched cohort (P = 0.541). Within the overall population, male sex remained independently associated with both in-hospital (OR: 2.26; 95% CI: 1.16-4.40) and long-term mortality (HR: 1.83; 95% CI: 1.32-2.52). Conclusions: Male TTS is featured by a distinct high-risk phenotype requiring close in-hospital monitoring and long-term follow-up. [ABSTRACT FROM AUTHOR]
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Gender Differences in Takotsubo Syndrome.
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Autor/in / Beteiligte Person: | Arcari, Luca ; Núñez Gil, Iván J. ; Stiermaier, Thomas ; El-Battrawy, Ibrahim ; Guerra, Federico ; Novo, Giuseppina ; Musumeci, Beatrice ; Cacciotti, Luca ; Mariano, Enrica ; Caldarola, Pasquale ; Parisi, Giuseppe ; Montisci, Roberta ; Vitale, Enrica ; Sclafani, Matteo ; Volpe, Massimo ; Corbì-Pasqual, Miguel ; Martinez-Selles, Manuel ; Almendro-Delia, Manuel ; Sionis, Alessandro ; Uribarri, Aitor |
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Zeitschrift: | Journal of the American College of Cardiology (JACC), Jg. 79 (2022-05-31), Heft 21, S. 2085-2093 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 0735-1097 (print) |
DOI: | 10.1016/j.jacc.2022.03.366 |
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