Activity of protein C, protein S and antithrombin 3 in COVID-19 patients treated with different modalities of oxygen supplementation.
In: Turkish Journal of Biochemistry / Turk Biyokimya Dergisi, 2024-04-25, S. 1-9
Online
academicJournal
Zugriff:
COVID-19 in it is more severe form is characterized by a hyperinflammatory condition, hypercoagulation state and the appearance of pulmonary microembolism. In this study we wanted to correlate levels of D-Dimer, protein C, protein S and antithrombin 3 with severity of disease and clinical outcome.We included 134 of patients who were divided in 3 groups regarding oxygen support (high flow oxygen therapy, mechanical ventilation and oxygen supplementation with nasal cannula or mask).Concentration of D-Dimer, and activity of protein C and antithrombin 3 are presented as mean±SD and differed significantly between patients on mechanical ventilation (3.26 ± 1.15 mg/L, 86 ± 22.55 %, 81.21 ± 17.61 %)/HFNO (2.35 ± 1.68 mg/L, 109.6 ± 26.96 %, 94.67 ± 17.49 %)/BNC (1.37 ± 1.17 mg/L, 116.92 ± 28.16 %, 103.29 ± 15.63 %) with p<0.001 for all parameters. Mortality in oxygen group was 10.9 %, in HFNC group 40.7 % and in mechanical ventilated group 80 %.determination of anticoagulant factors in COVID-19 patients may indicate which of them are at increased risk of developing severe disease, venous thromboembolism and fatal clinical outcome. [ABSTRACT FROM AUTHOR]
Titel: |
Activity of protein C, protein S and antithrombin 3 in COVID-19 patients treated with different modalities of oxygen supplementation.
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Autor/in / Beteiligte Person: | Ana, Šavuk ; Danijela, Grizelj ; Tomo, Svaguša ; Melanie-Ivana, Čulo ; Nikola, Zagorec ; Sara, Šakota ; Biserka, Orehovec ; Tomislav, Kelava ; Ana, Livun ; Ivan, Marković ; Josip, Baković ; Tatjana, Kereš |
Link: | |
Zeitschrift: | Turkish Journal of Biochemistry / Turk Biyokimya Dergisi, 2024-04-25, S. 1-9 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 0250-4685 (print) |
DOI: | 10.1515/tjb-2023-0119 |
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