Physicochemical mechanism of the wobble DNA base pairs Gua·Thy and AdeCyt transition into the mismatched base pairs Gua*·Thy and Ade·Cyt* formed by the mutagenic tautomers.
In: Ukrainica Bioorganica Acta, Jg. 7 (2009-12-15), Heft 2, S. 12-18
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Zugriff:
For the first time the new physicochemical mechanism has been proposed and grounded in order to underastand the origin of the spontaneous transitions. It is based on the tautomerization, induced by the interaction of the DNA-polymerase recognition center with the canonic nucleotide bases, of the pyrimidine bases in wobble base pairs Gua·Thy and Ade·Cyt which transition into the pairs Gua*·Thy and Ade·Cyt* accordingly. [ABSTRACT FROM AUTHOR]
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Physicochemical mechanism of the wobble DNA base pairs Gua·Thy and AdeCyt transition into the mismatched base pairs Gua*·Thy and Ade·Cyt* formed by the mutagenic tautomers.
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Autor/in / Beteiligte Person: | Brovarets, O. O. ; Hovorun, D. M. |
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Zeitschrift: | Ukrainica Bioorganica Acta, Jg. 7 (2009-12-15), Heft 2, S. 12-18 |
Veröffentlichung: | 2009 |
Medientyp: | academicJournal |
ISSN: | 1814-9758 (print) |
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