Optimizing utilization of kidneys from deceased donors over 60 years: Five-year outcomes after implementation of a combined clinical and histological allocation algorithm.
In: Transplant International, Jg. 26 (2013-08-01), Heft 8, S. 833-841
Online
academicJournal
Zugriff:
This 5 year observational multicentre study conducted in the Nord Italian Transplant programme area evaluated outcomes in patients receiving kidneys from donors over 60 years allocated according to a combined clinical and histological algorithm. Low-risk donors 60-69 years without risk factors were allocated to single kidney transplant (LR-SKT) based on clinical criteria. Biopsy was performed in donors over 70 years or 60-69 years with risk factors, allocated to Single (HR-SKT) or Dual kidney transplant (HR-DKT) according to the severity of histological damage. Forty HR-DKTs, 41 HR-SKTs and 234 LR-SKTs were evaluated. Baseline differences generally reflected stratification and allocation criteria. Patient and graft (death censored) survival were 90% and 92% for HR-DKT, 85% and 89% for HR-SKT, 88% and 87% for LR-SKT. The algorithm appeared user-friendly in daily practice and was safe and efficient, as demonstrated by satisfactory outcomes in all groups at 5 years. Clinical criteria performed well in low-risk donors. The excellent outcomes observed in DKTs call for fine-tuning of cut-off scores for allocation to DKT or SKT in high-risk patients. [ABSTRACT FROM AUTHOR]
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Optimizing utilization of kidneys from deceased donors over 60 years: Five-year outcomes after implementation of a combined clinical and histological allocation algorithm.
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Autor/in / Beteiligte Person: | Sefora, Pierobon Elisa ; Silvio, Sandrini ; Nicola, De Fazio ; Giuseppe, Rossini ; Iris, Fontana ; Luigino, Boschiero ; Maria, Gropuzzo ; Eliana, Gotti ; Donato, Donati ; Enrico, Minetti ; Teresa, Gandolfo Maria ; Anna, Brunello ; Carmelo, Libetta ; Antonio, Secchi ; Stefano, Chiaramonte ; Paolo, Rigotti |
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Zeitschrift: | Transplant International, Jg. 26 (2013-08-01), Heft 8, S. 833-841 |
Veröffentlichung: | 2013 |
Medientyp: | academicJournal |
ISSN: | 0934-0874 (print) |
DOI: | 10.1111/tri.12135 |
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