Ventricular reshaping with a beating heart implant improves pump function in experimental heart failure.
In: Journal of Thoracic & Cardiovascular Surgery, Jg. 163 (2022-05-01), Heft 5, S. e343- (13S.)
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Zugriff:
The left ventricle remodels from an ellipsoidal/conical shape to a spherical shape after a myocardial infarction. The spherical ventricle is inefficient as a pumping chamber, has higher wall stresses, and can lead to congestive heart failure. We sought to investigate if restoring physiological ventricular shape with a beating heart implant improves pump function. Rats were induced with a myocardial infarction, developing left ventricular dilatation and dysfunction, and becoming spherical over 3 weeks. Thereafter, they were randomized to undergo left ventricular reshaping with a beating heart implant (n = 19) or continue follow-up without an implant (n = 19). Biweekly echocardiography was performed until 12 weeks, with half the rats euthanized at 6 weeks and remaining at 12 weeks. At termination, invasive hemodynamic parameters and histopathology were performed. At 3 weeks after the infarction, rats had a 22% fall in ejection fraction, 31% rise in end diastolic volume, and 23% rise in sphericity. Transventricular implant reshaping reduced the volume by 12.6% and sphericity by 21%, restoring physiologic ventricular shape and wall stress. Over the 12-week follow-up, pump function improved significantly with better ventricular-vascular coupling in the reshaped hearts. In this group, cardiomyocyte cross-section area was higher and the cells were less elongated. Reshaping a postinfarction, failing left ventricle to restore its physiological conical shape significantly improves long-term pump function. [Display omitted] [ABSTRACT FROM AUTHOR]
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Titel: |
Ventricular reshaping with a beating heart implant improves pump function in experimental heart failure.
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Autor/in / Beteiligte Person: | Onohara, Daisuke ; Corporan, Daniella M. ; Kono, Takanori ; Kumar, Sandeep ; Guyton, Robert A. ; Padala, Muralidhar |
Link: | |
Zeitschrift: | Journal of Thoracic & Cardiovascular Surgery, Jg. 163 (2022-05-01), Heft 5, S. e343- (13S.) |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 0022-5223 (print) |
DOI: | 10.1016/j.jtcvs.2020.08.097 |
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