Occupational and domestic exposure associations with cerebral small vessel disease and vascular dementia: A systematic review and meta‐analysis.
In: Alzheimer's & Dementia: The Journal of the Alzheimer's Association, Jg. 20 (2024-04-01), Heft 4, S. 3021-3033
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Zugriff:
INTRODUCTION: The prevalence of cerebral smallvessel disease (SVD) and vascular dementia according to workplace or domestic exposure to hazardous substances is unclear. METHODS: We included studies assessing occupational and domestic hazards/at‐risk occupations and SVD features. We pooled prevalence estimates using random‐effects models where possible, or presented a narrative synthesis. RESULTS: We included 85 studies (n = 47,743, mean age = 44·5 years). 52/85 reported poolable estimates. SVD prevalence in populations exposed to carbon monoxide was 81%(95% CI = 60‐93%; n = 1373; results unchanged in meta‐regression), carbon disulfide73% (95% CI = 54‐87%; n = 131), 1,2‐dichloroethane 88% (95% CI = 4‐100%, n = 40), toluene 82% (95% CI = 3‐100%, n = 64), high altitude 49% (95% CI = 38‐60%; n = 164),and diving 24% (95% CI = 5‐67%, n = 172). We narratively reviewed vascular dementia studies and contact sport, lead, military, pesticide, and solvent exposures as estimates were too few/varied to pool. DISCUSSION: SVD and vascular dementia may be associated with occupational/domestic exposure to hazardous substances. CRD42021297800. [ABSTRACT FROM AUTHOR]
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Titel: |
Occupational and domestic exposure associations with cerebral small vessel disease and vascular dementia: A systematic review and meta‐analysis.
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Autor/in / Beteiligte Person: | Clancy, Una ; Cheng, Yajun ; Brara, Amrita ; Doubal, Fergus N. ; Wardlaw, Joanna M. |
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Zeitschrift: | Alzheimer's & Dementia: The Journal of the Alzheimer's Association, Jg. 20 (2024-04-01), Heft 4, S. 3021-3033 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 1552-5260 (print) |
DOI: | 10.1002/alz.13647 |
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