Medial temporal lobe gray matter microstructure in preclinical Alzheimer's disease.
In: Alzheimer's & Dementia: The Journal of the Alzheimer's Association, Jg. 20 (2024-06-01), Heft 6, S. 4147-4158
Online
academicJournal
Zugriff:
INTRODUCTION: Typical MRI measures of neurodegeneration have limited sensitivity in early disease stages. Diffusion MRI (dMRI) microstructural measures may allow for detection in preclinical stages. METHODS: Participants had dMRI and either beta‐amyloid PET or plasma biomarkers of Alzheimer's pathology within 18 months of MRI. Microstructure was measured in portions of the medial temporal lobe (MTL) with high neurofibrillary tangle (NFT) burden based on a previously developed post mortem 3D‐map. Regressions examined relationships between microstructure and markers of Alzheimer's pathology in preclinical disease and then across disease stages. RESULTS: There was higher isometric volume fraction in amyloid‐positive compared to amyloid‐negative cognitively unimpaired individuals in high tangle MTL regions. Similarly, plasma biomarkers and 18F‐flortaucipir were associated with microstructural changes in preclinical disease. Additional microstructural effects were seen across disease stages. DISCUSSION: Combining a post mortem atlas of NFT pathology with microstructural measures allows for detection of neurodegeneration in preclinical Alzheimer's disease. Highlights: Typical markers of neurodegeneration are not sensitive in preclinical Alzheimer's.dMRI measured microstructure in regions with high NFT.Microstructural changes occur in medial temporal regions in preclinical disease.Microstructural changes occur in other typical Alzheimer's regions in later stages.Combining post mortem pathology atlases with in vivo MRI is a powerful framework. [ABSTRACT FROM AUTHOR]
Copyright of Alzheimer's & Dementia: The Journal of the Alzheimer's Association is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Medial temporal lobe gray matter microstructure in preclinical Alzheimer's disease.
|
---|---|
Autor/in / Beteiligte Person: | Brown, Christopher ; Das, Sandhitsu ; Xie, Long ; Nasrallah, Ilya ; Detre, John ; Chen‐Plotkin, Alice ; Shaw, Leslie ; McMillan, Corey ; Yushkevich, Paul ; Wolk, David |
Link: | |
Zeitschrift: | Alzheimer's & Dementia: The Journal of the Alzheimer's Association, Jg. 20 (2024-06-01), Heft 6, S. 4147-4158 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 1552-5260 (print) |
DOI: | 10.1002/alz.13832 |
Sonstiges: |
|