Serial day rapid kindling is an effective tool in screening the anti-epileptic properties of topiramate.
In: Seizure, Jg. 16 (2007-10-01), Heft 7, S. 620-626
Online
academicJournal
Zugriff:
Summary: Introduction: In this study, a serial day rapid kindling protocol was used to fully kindle rats in a matter of days. Subsequently, the anticonvulsant profile of a relatively new anti-epileptic drug, topiramate, was evaluated in a cross-over design to further validate this rapid kindling model. Methods: Rats were kindled during three consecutive days, according to the serial day rapid kindling protocol. Topiramate was tested at a dose of 100mg/kg, i.p., over the next 2 days using a cross-over design. The stability of the kindled state was evaluated in all rats during two retest paradigms. During the drug-testing procedure, rats received a single i.p. injection of either topiramate or verhicle. Starting 1h later the rats received additional kindling stimulations during which their response was measured. Results: Serial day rapid kindling induced a long lasting and stable fully kindled state that allowed for the anti-epileptic drug screening procedure. Topiramate reduced both the afterdischarge duration and ameliorated seizure semiology in the kindled rats. Discussion: Serial day rapid kindling provided a tool to rapidly kindle rats in 3 days. Using a cross-over design, clear indications on anti-epileptic activity of a given drug can be determined using few laboratory animals. [Copyright &y& Elsevier]
Copyright of Seizure is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Serial day rapid kindling is an effective tool in screening the anti-epileptic properties of topiramate.
|
---|---|
Autor/in / Beteiligte Person: | De Smedt, Tim ; De Rouck, S. ; Raedt, R. ; Wyckhuys, T. ; Waterschoot, L. ; De Herdt, V. ; Van Dycke, A. ; Tahry, R. El ; Vonck, K. ; Boon, P. |
Link: | |
Zeitschrift: | Seizure, Jg. 16 (2007-10-01), Heft 7, S. 620-626 |
Veröffentlichung: | 2007 |
Medientyp: | academicJournal |
ISSN: | 1059-1311 (print) |
DOI: | 10.1016/j.seizure.2007.04.013 |
Schlagwort: |
|
Sonstiges: |
|