Comparing the Population Pharmacokinetics of and Acute Kidney Injury Due to Polymyxin B in Chinese Patients with or without Renal Insufficiency
In: Antimicrobial Agents and Chemotherapy, Jg. 65 (2021-01-20), Heft 2, S. e01900-20- (200188121S.)
Online
serialPeriodical
Zugriff:
Despite excellent bactericidal effect, dosing adjustment of polymyxin B for patients with renal insufficiency and polymyxin B-related nephrotoxicity is still a major concern to clinicians. The aim of this study was to compare the population pharmacokinetics (PK) properties of polymyxin B in Chinese patients with different renal functions and to investigate the relationship between PK parameters and polymyxin B-related acute kidney injury (AKI). A total of 37 patients with normal renal function (creatinine clearance ≥ 80 ml/min) and 33 with renal insufficiency (creatinine clearance < 80 ml/min) were included.
Titel: |
Comparing the Population Pharmacokinetics of and Acute Kidney Injury Due to Polymyxin B in Chinese Patients with or without Renal Insufficiency
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Autor/in / Beteiligte Person: | Wang, Peile ; Zhang, Qiwen ; Zhu, Zhenfeng ; Pei, Hui ; Feng, Min ; Sun, Tongwen ; Yang, Jing ; Zhang, Xiaojian |
Link: | |
Zeitschrift: | Antimicrobial Agents and Chemotherapy, Jg. 65 (2021-01-20), Heft 2, S. e01900-20- (200188121S.) |
Veröffentlichung: | 2021 |
Medientyp: | serialPeriodical |
ISSN: | 0066-4804 (print) ; 1098-6596 (print) |
DOI: | 10.1128/AAC.01900-20 |
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