Differential In VitroActivities of Individual Drugs and Bedaquiline-Rifabutin Combinations against Actively Multiplying and Nutrient-Starved Mycobacterium abscessus
In: Antimicrobial Agents and Chemotherapy, Jg. 65 (2021-01-20), Heft 2, S. e02179-20- (200215742S.)
Online
serialPeriodical
Zugriff:
Current treatment options for lung disease caused by Mycobacterium abscessuscomplex infections have limited effectiveness. To maximize the use of existing antibacterials and to help inform regimen design for treatment, we assessed the in vitrobactericidal activity of single drugs against actively multiplying and net nonreplicating M. abscessuspopulations in nutrient-rich and nutrient-starvation conditions, respectively. As single drugs, bedaquiline and rifabutin exerted bactericidal activity only against nutrient-starved and actively growing M. abscessus, respectively.
Titel: |
Differential In VitroActivities of Individual Drugs and Bedaquiline-Rifabutin Combinations against Actively Multiplying and Nutrient-Starved Mycobacterium abscessus
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Autor/in / Beteiligte Person: | Lee, Jin ; Ammerman, Nicole ; Agarwal, Anusha ; Naji, Maram ; Li, Si-Yang ; Nuermberger, Eric |
Link: | |
Zeitschrift: | Antimicrobial Agents and Chemotherapy, Jg. 65 (2021-01-20), Heft 2, S. e02179-20- (200215742S.) |
Veröffentlichung: | 2021 |
Medientyp: | serialPeriodical |
ISSN: | 0066-4804 (print) ; 1098-6596 (print) |
DOI: | 10.1128/AAC.02179-20 |
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