Selective homing of CAR-CIK cells to the bone marrow niche enhances control of the acute myeloid leukemia burden
In: Blood, Jg. 141 (2023-05-25), Heft 21, S. 2587-2598
Online
serialPeriodical
Zugriff:
•CAR T-cell therapy in AML is hampered by the poor accumulation of effector cells in the BM niche in which leukemic stem cells are nested.•Engineering CAR-CIKs with CXCR4 promotes their homing in the BM and improves their antileukemic efficacy in AML.
Titel: |
Selective homing of CAR-CIK cells to the bone marrow niche enhances control of the acute myeloid leukemia burden
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Autor/in / Beteiligte Person: | Biondi, Marta ; Tettamanti, Sarah ; Galimberti, Stefania ; Cerina, Beatrice ; Tomasoni, Chiara ; Piazza, Rocco ; Donsante, Samantha ; Bido, Simone ; Perriello, Vincenzo Maria ; Broccoli, Vania ; Doni, Andrea ; Dazzi, Francesco ; Mantovani, Alberto ; Dotti, Gianpietro ; Biondi, Andrea ; Pievani, Alice ; Serafini, Marta |
Link: | |
Zeitschrift: | Blood, Jg. 141 (2023-05-25), Heft 21, S. 2587-2598 |
Veröffentlichung: | 2023 |
Medientyp: | serialPeriodical |
ISSN: | 0006-4971 (print) ; 1528-0020 (print) |
DOI: | 10.1182/blood.2022018330 |
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