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Childhood cancer or pediatric cancer is one of the leading causes of death among children. Treatment strategies for pediatric cancers include chemotherapy, surgery, radiation, and stem cell transplantation. These therapeutic regimens are well known to develop highly toxic and long-lasting side-effects including secondary cancers in the future lifespan of pediatric patients. Despite these intensive therapeutic regimens, cancer may still relapse as refractory and metastatic cancer. Therefore, further understanding the causes of different pediatric cancers, mechanisms of drug-resistance, and causes of relapse and metastasis is required for developing and advancing less toxic and more effective therapeutic strategies for pediatric cancers. Recent advancements in immunotherapies and targeted therapeutic approaches using pharmacological inhibitors are one step in this direction.In this Special Issue of Cancers, authors contributed original research and review articles focusing on different aspects of pediatric cancer development, causes, maintenance, and therapeutic strategies. The collected articles in this Special Issue will further enhance our knowledge and understanding of pediatric cancers and drive the development of novel therapeutic strategies.

Titel:	Pediatric Cancers
Autor/in / Beteiligte Person:	Agarwal, Saurabh ; Yang, Jianhua
Link:	View record at Directory of Open Access Books (Volltext)
Veröffentlichung:	Basel: MDPI - Multidisciplinary Digital Publishing Institute, 2023
Medientyp:	E-Book
Umfang:	456
ISBN:	978-3-0365-9024-0 (print) ; 978-3-0365-9025-7 (print)
DOI:	10.3390/books978-3-0365-9025-7
Schlagwort:	infections cancer children bacteremia pneumonia sarcoma solid tumor outcome KI67 EZRIN 18F-FDG PET/CT random forest radiogenomics chemotherapy response metastasis serine-threonine kinase receptor-associated protein neuroblastoma CRISPR-Cas9 metronomic chemotherapy maintenance therapy high-risk Ewing sarcoma RNA-binding proteins regulation network prognosis prediction risk model melanotic neuroectodermal tumor of infancy inoperable metastatic recurrent chemotherapy adjuvant neoadjuvant systemic treatment childhood malignant bone tumors survivorship late effects somatic disease cohort study rhabdomyosarcoma targeted therapies cell surface proteomics B7-H3 stress allostasis stress regulatory pathways stress dysregulation stress reactivity early life stress childhood cancer cytotoxic cancer treatment interventions ependymoma risk stratification molecular group prognosis nephroblastoma clinical malformations cancer predisposition syndromes tumor surveillance DSRCT EWSR1-WT1 preclinical model in vitro model pediatric cancer pediatric brain tumor medulloblastoma glioma natural products drug discovery fungal secondary metabolites soil microbes RH30 RD EZH2 epigenetic EPZ005687 DZNep AdOx malignant rhabdoid tumor hepatoblastoma small cell undifferentiated (SCUD) hepatoblastoma SMARCB1 INI1 pediatric liver tumors drug repurposing PI3K pathway epigenetics Fimepinostat LPAR1 LPA tumor metastasis bioinformatics analysis ulixertinib ERK inhibition combination therapy c-Myc/N-Myc cell differentiation ATRA SOX4 diffuse intrinsic pontine glioma immunotherapy immune microenvironment immune checkpoint inhibitor vaccine oncolytic virus myeloid sarcoma chloroma acute myeloid leukemia pediatric cancers VIPN DIC MDR drug transporters childhood acute leukemia early complication hyperleukocytosis risk factor survival outcome bic Book Industry Communication:M Medicine bic Book Industry Communication:M Medicine:MJ Clinical & internal medicine:MJC Diseases & disorders:MJCL Oncology
Sonstiges:	Nachgewiesen in: Directory of Open Access Books Sprachen: English Document Type: eBook File Description: application/octet-stream Language: English Rights: Attribution 4.0 International ; URL: https://creativecommons.org/licenses/by/4.0/ Notes: ONIX_20231130_9783036590240_93

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Pediatric Cancers