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Mitochondrial transporters are membrane-inserted proteins which provide a link between metabolic reactions occurring within the mitochondrial matrix and outside the organelles by catalyzing the translocation of numerous solutes across the mitochondrial membrane. They include the mitochondrial carrier family members, the proteins involved in pyruvate transport, ABC transporters and channels, and are, therefore, essential for many biological processes and cell homeostasis. Identification and functional studies of many mitochondrial transporters have been performed over the years using both in vitro and in vivo systems. The few recently solved structures of these transporters have paved the way for further investigations. Furthermore, alterations in their function are responsible for several diseases.

Titel:	Mitochondrial Transport Proteins
Autor/in / Beteiligte Person:	Palmieri, Ferdinando
Link:	View record at Directory of Open Access Books (Volltext)
Veröffentlichung:	Basel: MDPI - Multidisciplinary Digital Publishing Institute, 2022
Medientyp:	E-Book
Umfang:	476
ISBN:	978-3-0365-3410-7 (print) ; 978-3-0365-3409-1 (print)
DOI:	10.3390/books978-3-0365-3409-1
Schlagwort:	hypoxia resistance to hypoxia mitochondria mitochondrial calcium transport mitochondrial calcium uniporter complex mitochondrial Ca2+-induced permeability transition pore cyclophilin D ATP synthase disease error of metabolism mitochondrial carrier mitochondrial carrier disease mitochondrial disease mitochondrial transporter membrane transport mutation SLC25. mitochondrial permeability transition apoptosis necrosis ischemia/reperfusion cancer neurodegeneration cyclosporin A metabolite transport mitochondrial pyruvate carrier sideroflexin TOM TIM chaperones TIM22 protein translocation mitochondrial biogenesis amino acid biological function ion inner mitochondrial membrane mitochondrial carrier family organic acid substrate specificity transport mechanism vitamin USMG5/DAPIT glucose-stimulated insulin secretion glucose-induced expression membrane subunits of ATP synthase ATP synthase oligomers mitochondrial cristae morphology metabolism metabolic disorders adult-onset type II citrullinemia (CTLN2) aspartate/glutamate carrier (AGC) animal model argininosuccinate synthetase (ASS) aversion to carbohydrates citrin food taste neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) protein–protein interaction MPC lifespan pyruvate metabolism mitochondrial transport peroxisomes carrier cofactor ABC transporter aquaporin ion channels potassium channels ATP calcium ROS potassium channel openers MCF function plant metabolism plant development diseases VDAC1 virus pancreatic islets β-cell diabetes glucotoxicity glucolipotoxicity lipotoxicity mitochondrial carriers SLC transporters SLC25 SLC54 SLC55 LETM SLC56 sequence analysis protein targeting Voltage-Dependent Anion selective Channel isoforms oxidative post-translational modification gene promoter yeast bioenergetics SLC25A1 CIC CTP citrate inflammation 22.q11.2 NAFLD/NASH carnitine carnitine acyl-carnitine carrier carnitine acyl-carnitine translocase post-translational modification solute carrier family 25 SLC25A20 MCU mitochondrial Ca2+ uniporter Ca2+ signaling mitochondrial metabolism skeletal muscle mitochondria SLC25A51 NAD+ transporters NAD electrophysiology ATP-dependent potassium channel bic Book Industry Communication:G Reference, information & interdisciplinary subjects:GP Research & information: general bic Book Industry Communication:P Mathematics & science:PS Biology, life sciences
Sonstiges:	Nachgewiesen in: Directory of Open Access Books Sprachen: English Document Type: eBook File Description: image/jpeg Language: English Rights: Attribution 4.0 International ; URL: https://creativecommons.org/licenses/by/4.0/ Notes: ONIX_20220506_9783036534107_14

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Mitochondrial Transport Proteins