Expression and clinical value of CXCR4 in high grade gastroenteropancreatic neuroendocrine neoplasms
In: Frontiers in Endocrinology, Jg. 15 (2024-03-01)
Online
academicJournal
Zugriff:
BackgroundCXC chemokine receptor 4 (CXCR4) is associated with the progression and metastasis of numerous malignant tumors. However, its relationship with Gastroenteropancreatic Neuroendocrine Neoplasms Grade 3 (GEP-NENs G3) is unclear. The aim of this study was to characterize the expression of CXCR4 in GEP-NENS and to explore the clinical and prognostic value of CXCR4.MethodsThis study retrospectively collected clinical and pathological data from patients with GEP-NENs who receiving surgery in Qilu Hospital of Shandong University from January 2013 to April 2021, and obtained the overall survival of the patients based on follow-up. Immunohistochemistry (IHC) was performed on pathological paraffin sections to observe CXCR4 staining. Groups were made according to pathological findings. Kaplan-Meier (K-M) curve was used to evaluate prognosis. SPSS 26.0 was used for statistical analysis.Results100 GEP-NENs G3 patients were enrolled in this study. There was a significant difference in primary sites (P=0.002), Ki-67 index (P
Titel: |
Expression and clinical value of CXCR4 in high grade gastroenteropancreatic neuroendocrine neoplasms
|
---|---|
Autor/in / Beteiligte Person: | Pang, Chaoyu ; Li, Yongzheng ; Shi, Ming ; Fan, Zhiyao ; Gao, Xin ; Meng, Yufan ; Liu, Shujie ; Gao, Changhao ; Su, Peng ; Wang, Xiao ; Zhan, Hanxiang |
Link: | |
Zeitschrift: | Frontiers in Endocrinology, Jg. 15 (2024-03-01) |
Veröffentlichung: | Frontiers Media S.A., 2024 |
Medientyp: | academicJournal |
ISSN: | 1664-2392 (print) |
DOI: | 10.3389/fendo.2024.1281622 |
Schlagwort: |
|
Sonstiges: |
|