Alemtuzumab treatment for multiple sclerosis in Austria: An observational long‐term outcome study
In: Annals of Clinical and Translational Neurology, Jg. 11 (2024), Heft 6, S. 1442-1455
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Zugriff:
Abstract Background/Objective Observational real‐world study to analyze the clinical effects of alemtuzumab (ALEM) and subsequent disease‐modifying therapy (DMT) usage in multiple sclerosis (MS). Methods Data retrieved from the Austrian MS treatment registry (AMSTR) included baseline (BL) characteristics (at ALEM start), annualized relapse rate (ARR), 6‐month confirmed progression independent of relapse activity (PIRA; ≥ 0.5‐point Expanded Disability Status Scale (EDSS) score increase), 6‐month confirmed disability improvement (CDI; ≥ 0.5‐point EDSS decrease), and safety outcomes until initiation of a subsequent DMT. The EDSS was re‐baselined at 30 days from ALEM start (BL EDSS). Results Eighty‐seven ALEM‐treated patients (median age: 32 years, 72% female, 14% treatment‐naïve) were followed for a median of 55 (interquartile range 31–68) months. We found significant reductions in the ARR from 1.16 before ALEM to 0.15 throughout Years 1–9 (p
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Alemtuzumab treatment for multiple sclerosis in Austria: An observational long‐term outcome study
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Autor/in / Beteiligte Person: | Moser, Tobias ; Foettinger, Fabian ; Hitzl, Wolfgang ; Novotna, Bianka ; Berger, Thomas ; Bsteh, Gabriel ; Franziska Di Pauli ; Hegen, Harald ; Kornek, Barbara ; Langenscheidt, Dieter ; Sellner, Johann |
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Zeitschrift: | Annals of Clinical and Translational Neurology, Jg. 11 (2024), Heft 6, S. 1442-1455 |
Veröffentlichung: | Wiley, 2024 |
Medientyp: | academicJournal |
ISSN: | 2328-9503 (print) |
DOI: | 10.1002/acn3.52056 |
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