Coordination Ion Spray for Analysis of the Growth Hormones Releasing Peptides in Urine—An Application Study
In: Separations, Jg. 11 (2024-05-01), Heft 5, S. 155-155
Online
academicJournal
Zugriff:
In this article, a comparison of ionization techniques is provided and discussed. Conventional liquid chromatography with an electrospray ionization source shows higher robustness and repeatability in comparison with liquid chromatography coupled with a coordination ion spray (CIS-MS) source using silver nitrate as the dopant. However, the higher sensitivity and possibility to collect more data in untargeted applications mean CIS-MS is emerging as an instrument used in specific applications. During this research, the limit of detection (LOD) for GHRP-2 and GHRP-6 was established at 0.2 ng/mL, and the lower limit of quantification (LLOQ) was 0.5 ng/mL for CIS-MS. For conventional ESI-MS combined with solid-phase extraction on weak cation exchange columns, the limit of detection was found to be 1 ng/mL, and the lower limit of quantification was 2 ng/mL.
Titel: |
Coordination Ion Spray for Analysis of the Growth Hormones Releasing Peptides in Urine—An Application Study
|
---|---|
Autor/in / Beteiligte Person: | Temerdashev, Azamat ; Gashimova, Elina ; Azaryan, Alice ; Feng, Yu-Qi ; Atapattu, Sanka N. |
Link: | |
Zeitschrift: | Separations, Jg. 11 (2024-05-01), Heft 5, S. 155-155 |
Veröffentlichung: | MDPI AG, 2024 |
Medientyp: | academicJournal |
ISSN: | 2297-8739 (print) |
DOI: | 10.3390/separations11050155 |
Schlagwort: |
|
Sonstiges: |
|