The relationship between innate/adaptive immunity and gastrointestinal cancer : a multi-omics Mendelian randomization study
In: BMC Gastroenterology, Jg. 24 (2024), Heft 1, S. 1-10
Online
academicJournal
Zugriff:
Abstract Background Innate/adaptive immunity is the key to anti-tumor therapy. However, its causal relationship to Gastrointestinal (GI) cancer remains unclear. Methods Immunity genes were extracted from the MSigDB database. The Genome-wide association studies (GWAS) summary data of GI cancer were integrated with expression quantitative trait loci (eQTL) and DNA methylation quantitative trait loci (mQTL) associated with genes. Summary-data-based Mendelian randomization (SMR) and co-localization analysis were used to reveal causal relationships between genes and GI cancer. Two-sample MR analysis was used for sensitivity analysis. Single cell analysis clarified the enrichment of genes. Results Three-step SMR analysis showed that a putative mechanism, cg17294865 CpG site regulating HLA-DRA expression was negatively associated with gastric cancer risk. HLA-DRA was significantly differentially expressed in monocyte/macrophage and myeloid cells in gastric cancer. Conclusion This study provides evidence that upregulating the expression level of HLA-DRA can reduce the risk of gastric cancer.
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The relationship between innate/adaptive immunity and gastrointestinal cancer : a multi-omics Mendelian randomization study
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Autor/in / Beteiligte Person: | Lv, Chen-Xi ; Zhou, Lin-Po ; Yang, Ye-Bing ; Shi, Jing ; Dong, Fan-He ; Wei, Hao-Ran ; Shan, Yu-Qiang |
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Zeitschrift: | BMC Gastroenterology, Jg. 24 (2024), Heft 1, S. 1-10 |
Veröffentlichung: | BMC, 2024 |
Medientyp: | academicJournal |
ISSN: | 1471-230X (print) |
DOI: | 10.1186/s12876-024-03284-x |
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