ROS-mediated cytoplasmic localization of CARM1 induces mitochondrial fission through DRP1 methylation
In: Redox Biology, Jg. 73 (2024-07-01), Heft 103212-
Online
academicJournal
Zugriff:
The dynamic regulation of mitochondria through fission and fusion is essential for maintaining cellular homeostasis. In this study, we discovered a role of coactivator-associated arginine methyltransferase 1 (CARM1) in mitochondrial dynamics. CARM1 methylates specific residues (R403 and R634) on dynamin-related protein 1 (DRP1). Methylated DRP1 interacts with mitochondrial fission factor (Mff) and forms self-assembly on the outer mitochondrial membrane, thereby triggering fission, reducing oxygen consumption, and increasing reactive oxygen species (ROS) production. This sets in motion a feedback loop that facilitates the translocation of CARM1 from the nucleus to the cytoplasm, enhancing DRP1 methylation and ROS production through mitochondrial fragmentation. Consequently, ROS reinforces the CARM1-DRP1-ROS axis, resulting in cellular senescence. Depletion of CARM1 or DRP1 impedes cellular senescence by reducing ROS accumulation. The uncovering of the above-described mechanism fills a missing piece in the vicious cycle of ROS-induced senescence and contributes to a better understanding of the aging process.
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ROS-mediated cytoplasmic localization of CARM1 induces mitochondrial fission through DRP1 methylation
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Autor/in / Beteiligte Person: | Cho, Yena ; Yong Kee Kim |
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Zeitschrift: | Redox Biology, Jg. 73 (2024-07-01), Heft 103212- |
Veröffentlichung: | Elsevier, 2024 |
Medientyp: | academicJournal |
ISSN: | 2213-2317 (print) |
DOI: | 10.1016/j.redox.2024.103212 |
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