Nature-Inspired Tetrahydropentalene Building Blocks: Scalable Synthesis for Medicinal Chemistry Needs
In: Журнал органічної та фармацевтичної хімії, Jg. 21 (2023), Heft 4, S. 43-50
Online
academicJournal
Zugriff:
Inspired by the bioactivity of natural compounds with a bicyclo[3.3.0]octane core, the study focuses on developing tetrahydropentalene-2,5-dione (2,5-THP-dione) derivatives as potential building blocks for the use in medicinal chemistry. Using the commercially available 2,5-THP-dione, a number of alkylated derivatives and a monofunctional ketone were synthesized. Using optimized protocols for synthesis, target compounds were obtained with high yields on a multigram scale. These compounds are promising derivatives for further chemical derivatization and therapeutic use, and thus highlight the value of 2,5-THP-dione in creating complex molecular structures for drug discovery, as well as the importance of tetrahydropentalene derivatives as valuable building blocks in synthetic chemistry.
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Nature-Inspired Tetrahydropentalene Building Blocks: Scalable Synthesis for Medicinal Chemistry Needs
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Autor/in / Beteiligte Person: | Smyrnov, Oleh K. ; Olexandr Ye. Pashenko |
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Zeitschrift: | Журнал органічної та фармацевтичної хімії, Jg. 21 (2023), Heft 4, S. 43-50 |
Veröffentlichung: | National University of Pharmacy (Kharkiv, Ukraine), 2023 |
Medientyp: | academicJournal |
ISSN: | 2308-8303 (print) ; 2518-1548 (print) |
DOI: | 10.24959/ophcj.23.299612 |
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