The Effects of Ischemic Preconditioning on Cardiac Ischemia-Reperfusion Injury in Rat Lung

Ischemia and reperfusion of a tissue or a viscera may also show a protective effect such as development of preconditioning on the other tissues which have another source of arterial blood flow. This mechanism of action is known as remote ischemic preconditioning. In this study, we have investigated the effects of preconditioning induced by pulmonary artery occlusion on myocardial ischemia and ischemia- reperfusion injury on a rat model. For this purpose, we used adult, in both sex , 30 Sprague-Dawley rats (n=6). There were five experimental groups; Group 1: Control (Sham operated), Group 2: 30 minute myocardial ischemia induced by left coronary artery occlusion, Group 3: 30 minute left coronary artery occlusion followed by 60 minute reperfusion, Group 4: Pulmonary ischemic preconditioning followed by 30 minute left coronary artery occlusion, Group 5: Pulmonary ischemic preconditioning followed by 30 minute left coronary artery occlusion and 60 minute reperfusion. Malonyldialdehyde and purine nucleotide levels of myocardial tissue were measured by high performance liquid chromatography. As a conclusion, remote preconditioning evoked by pulmonary artery occlusion and reperfusion may induce a protective effect against myocardial ischemia and ischemia- reperfusion injury. It can be suggested that the protective effect of remote preconditioning is related with myocardial adenosine.