Cytotoxic sulfoquinovosyl glycerols from the seaweed Sargassum Angustifolium from persian gulf
In: Advanced Biomedical Research, Jg. 13 (2024), Heft 1, S. 22-22
Online
academicJournal
Zugriff:
Backgrounds: Seaweeds are an important source of marine organisms that produce a lot of bioactive compounds. Materials and Methods: In this research, the seaweed Sargassum angustifolium was collected from Bushehr province of Persian Gulf of Iran. The seaweed was extracted by methanol:ethyl acetate (1:1) using maceration method. The compounds were isolated with different column chromatography and HPLC(High Performance Liquid Chromatography) by silica gel and hexane:ethyl acetate as mobile phase. Results: The isolated compounds were elucidated structurally by various 1 and 2 D-NMR and MS spectra. Besides the cytotoxicity test was done against HeLa using standard MTT assay and normal cells. Conclusion: It afforded four known sulfoquinovosyl diacylglycerides and fucosterol. Compounds 1-5 showed cytotoxic effects against HeLa and HUVEC cell lines, with IC50 values of 12.2 ± 2.3, 25.8 ± 3.7, 14.9 ± 2.6, 9.8 ± 1.2 μM, and 5.6 ± 1.2, respectively.
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Cytotoxic sulfoquinovosyl glycerols from the seaweed Sargassum Angustifolium from persian gulf
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| Autor/in / Beteiligte Person: | Seyed Ebrahim Sajjadi ; Ghobeishavi, Sahar ; Yegdaneh, Afsaneh |
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| Zeitschrift: | Advanced Biomedical Research, Jg. 13 (2024), Heft 1, S. 22-22 |
| Veröffentlichung: | Wolters Kluwer Medknow Publications, 2024 |
| Medientyp: | academicJournal |
| ISSN: | 2277-9175 (print) |
| DOI: | 10.4103/abr.abr_103_23 |
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