Role of TNF-α in the Pathogenesis of Migraine
In: Pain Research and Management, Jg. 2024 (2024)
Online
academicJournal
Zugriff:
Background. Neurogenic neuroinflammation has a wide role in migraine pathogenesis including the transition from episodic migraine to chronic one. The seed molecule of neurogenic neuroinflammation, i.e., the TNF-α proinflammatory molecule, has gathered a lot of attention. This pleiotropic cytokine is a classical component of inflammatory soup, secreted by the microglial cell, and promotes a wide range of inflammatory reactions. Aim. In this review, we aimed to provide a culminating and comprehending glimpse into the TNF-α in association with the migraine. Method. A systematic literature survey method with a mixture of keywords was utilized to grasp the different elements that represent the association between TNF-α and migraine. Discussion. Highlighted the probable involvement of the TNF-α with migraine, the complexity of the matter such as activation of NF-KB signaling cascade, autoactivation, sensitization, and increased likelihood of transition cannot be neglected. Being TNF-α as a core node, it becomes the factor for linking diseases such as chronic inflammatory disorders, including COVID-19, and also interaction with other genes to develop severe conditions. Conclusion. To this end, TNF-α plays a critical role in chronification, and inhibiting its signaling would likely be a crucial strategy for migraine therapy.
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Role of TNF-α in the Pathogenesis of Migraine
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Autor/in / Beteiligte Person: | Sudershan, Amrit ; Sudershan, Srishty ; Sharma, Isha ; Kumar, Hardeep ; Panjaliya, Rakesh K. ; Kumar, Parvinder |
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Zeitschrift: | Pain Research and Management, Jg. 2024 (2024) |
Veröffentlichung: | Hindawi Limited, 2024 |
Medientyp: | academicJournal |
ISSN: | 1918-1523 (print) |
DOI: | 10.1155/2024/1377143 |
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