Inflammatory activity evaluation in patients with axial spondyloarthritis using MRI relaxometry and mucosal-associated invariant T cells
In: Frontiers in Immunology, Jg. 15 (2024-05-01)
Online
academicJournal
Zugriff:
BackgroundCurrently, there is a lack of an objective quantitative measure to comprehensively evaluate the inflammatory activity of axSpA, which poses certain challenges in accurately assessing the disease activity.ObjectiveTo explore the value of combined-parameter models of sacroiliac joints (SIJs) MRI relaxometry and peripheral blood Mucosal-associated invariant T (MAIT) cells in evaluating the inflammatory activity of axial spondyloarthritis (axSpA).MethodsThis retrospective clinical study included 88 axSpA patients (median age 31.0 (22.0, 41.8) years, 21.6% females) and 20 controls (median age 28.0 (20.5, 49.5) years, 40.0% females). The axSpA group was classified into active subgroup (n=50) and inactive subgroup (n=38) based on ASDAS-CRP. All participants underwent SIJs MRI examination including T1 and T2* mapping, and peripheral blood flow cytometry analysis of MAIT cells (defined as CD3+Vα7.2+CD161+) and their activation markers (CD69). The T1 and T2* values, as were the percentages of MAIT cells and CD69+MAIT cells were compared between different groups. Combined-parameter models were established using logistic regression, and ROC curves were employed to evaluate the diagnostic efficacy.ResultsThe T1 values of SIJs and %CD69+MAIT cells in the axSpA group and its subgroup were higher than the control group (p
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Inflammatory activity evaluation in patients with axial spondyloarthritis using MRI relaxometry and mucosal-associated invariant T cells
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Autor/in / Beteiligte Person: | Yang, Shengsheng ; Zheng, Yonghong ; Chen, Xianyuan ; Lin, Mingui ; Dai, Xiaomin ; Gao, Fei ; Chen, Huangjing ; Ma, Mingping ; Yu, Shun |
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Zeitschrift: | Frontiers in Immunology, Jg. 15 (2024-05-01) |
Veröffentlichung: | Frontiers Media S.A., 2024 |
Medientyp: | academicJournal |
ISSN: | 1664-3224 (print) |
DOI: | 10.3389/fimmu.2024.1391280 |
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