Efficacy and safety of herbal medicine combined with acupuncture in pediatric epilepsy treatment: A meta-analysis of randomized controlled trials.
In: PLoS ONE, Jg. 19 (2024), Heft 5, S. e0303201
Online
academicJournal
Zugriff:
ObjectiveTo evaluate the efficacy and safety of herbal medicine and acupuncture combination for pediatric epilepsy treatment.MethodsDatabases were searched from their interception until October 2023 to identify randomized controlled trials focusing on the therapeutic efficacy of herbal medicine-acupuncture combination (intervention group) for pediatric epilepsy. The primary outcome was the risk of treatment failure, whereas the secondary outcomes included the risk of post-treatment electroencephalogram (EEG) abnormalities and adverse events. Subgroup analyses were conducted based on the type of herbal compound formulas. Meta-regression analysis was conducted to examine the influence of patient demographics and clinical history on the therapeutic efficacy of herbal medicine-acupuncture combination for pediatric epilepsy. To assess the cumulative evidence, trial sequential analysis (TSA) was performed.ResultsThe analysis included 10 trials involving a total of 882 pediatric patients. Meta-analysis revealed that the intervention group had a lower risk of treatment failure than the control group (risk ratio [RR] = 0.3, 95% confidence interval [CI]: 0.19-0.47, PConclusionThe meta-analysis suggested that combined use of herbal medicine and acupuncture is a promising and safe clinical approach for pediatric epilepsy treatment. Further large-scale studies are necessary to conclusively determine the efficacy and safety of herbal medicine and acupuncture in pediatric epilepsy treatment.
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Efficacy and safety of herbal medicine combined with acupuncture in pediatric epilepsy treatment: A meta-analysis of randomized controlled trials.
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Autor/in / Beteiligte Person: | Su, Hong-Wen ; Chen, Hsiao-Tien ; Kao, Chia-Li ; Hung, Kuo-Chuan ; Lin, Yao-Tsung ; Liu, Ping-Hsin ; Lin, Chien-Ming ; Chen, I-Wen |
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Zeitschrift: | PLoS ONE, Jg. 19 (2024), Heft 5, S. e0303201 |
Veröffentlichung: | Public Library of Science (PLoS), 2024 |
Medientyp: | academicJournal |
ISSN: | 1932-6203 (print) |
DOI: | 10.1371/journal.pone.0303201&type=printable |
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