Dopamine D1 receptor gene polymorphism and schizophrenia in Japan
In: American journal of medical genetics, Jg. 88 (1999), Heft 2, S. 116-119
Online
academicJournal
- print; 22 ref
Zugriff:
We studied the relationship between schizophrenia and the DdeI polymorphism in the 5' untranslated region (5'UTR) of the dopamine D1 receptor (DRD1) gene. This polymorphism is an A (A1 allele) to G (A2 allele) transition in the 5' UTR of exon 2 at bp -48 (A-48G). One hundred forty-eight schizophrenics and 148 control subjects were investigated. No significant differences in genotypic counts and allele frequencies between schizophrenics and controls were found. Although a significant difference between the patients classified as disorganized type and the controls was discovered both in genotypic counts and allele frequencies, neither association proved significant when a Bonferroni correction was used. Moreover, there were no differences in scores of main symptoms of schizophrenia based on the Manchester Scale between patients with A1/A1 genotype and those with A1/A2 genotype. These findings suggest that this gene may not be involved in the pathogenesis of schizophrenia.
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Dopamine D1 receptor gene polymorphism and schizophrenia in Japan
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Autor/in / Beteiligte Person: | KOJIMA, H ; OHMORI, O ; SHINKAI, T ; TERAO, T ; SUZUKI, T ; ABE, K |
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Zeitschrift: | American journal of medical genetics, Jg. 88 (1999), Heft 2, S. 116-119 |
Veröffentlichung: | New York, NY: Wiley-Liss, 1999 |
Medientyp: | academicJournal |
Umfang: | print; 22 ref |
ISSN: | 0148-7299 (print) |
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