The effects of amphetamine exposure on outcome-selective Pavlovian-instrumental transfer in rats
In: Psychopharmacologia, Jg. 223 (2012), Heft 3, S. 361-370
Online
academicJournal
- print; 10; 1 p.1/4
Zugriff:
Rationale Repeated exposure to psychostimulants alters behavioral responses to reward-related cues; however, the motivational underpinnings of this effect have not been fully characterized. Objectives The following study was designed to examine how amphetamine sensitization affects performance in rats on a series of Pavlovian and operant tasks that distinguish between general-incentive and outcome-selective forms of conditioned responses. Methods Adult male rats underwent Pavlovian and instrumental training for food pellet rewards. Following training, rats were sensitized to D-amphetamine (2 mg/kg for 7 days). Rats were subsequently tested on an outcome-selective Pavlovian-instrumental transfer (PIT) task, an outcome-reinstatement task, and an outcome devaluation task. Additionally, in a separate experiment, PIT was assessed in amphetamine-sensitized and control rats using a Pavlovian backward-conditioned stimulus. Results Repeated amphetamine exposure sensitized locomotor activity to acute amphetamine challenge. Amphetamine altered responses to CS presentations by increasing conditioned approach. During tests of PIT, amphetamine-treated rats showed no outcome-selectivity in their responding, responding to a CS whether or not it shared a common outcome with the instrumental response. No effect of amphetamine sensitization was observed on tests of outcome-selective reinstatement by outcome delivery or action selection based on outcome value. Amphetamine-sensitized rats showed impaired outcome-selective PIT to a backward CS but were unaltered in conditioned approach. Conclusions Amphetamine sensitization prevents outcome-selective responding during PIT, which is dissociable from amphetamine's effects on conditioned approach. These data suggest fundamental alterations in how stimuli motivate action in addiction.
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The effects of amphetamine exposure on outcome-selective Pavlovian-instrumental transfer in rats
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Autor/in / Beteiligte Person: | SHIFLETT, Michael W |
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Zeitschrift: | Psychopharmacologia, Jg. 223 (2012), Heft 3, S. 361-370 |
Veröffentlichung: | Berlin: Springer, 2012 |
Medientyp: | academicJournal |
Umfang: | print; 10; 1 p.1/4 |
ISSN: | 0033-3158 (print) |
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