The association between low vitamin D and depressive disorders
In: Molecular psychiatry, Jg. 19 (2014), Heft 4, S. 444-451
Online
academicJournal
- print; 8; 57 ref
Zugriff:
It has been hypothesized that hypovitaminosis D is associated with depression but epidemiological evidence is limited. We investigated the association between depressive disorders and related clinical characteristics with blood concentrations of 25-hydroxyvitamin D [25(OH)D] in a large cohort. The sample consisted of participants (aged 18-65 years) from the Netherlands Study of Depression and Anxiety (NESDA) with a current (N = 1102) or remitted (N = 790) depressive disorder (major depressive disorder, dysthymia) defined according to DSM-IV criteria, and healthy controls (N = 494). Serum levels of 25(OH)D measured and analyzed in multivariate analyses adjusting for sociodemographics, sunlight, urbanization, lifestyle and health. Of the sample, 33.6% had deficient or insufficient serum 25(OH)D (<50 nmoll-1). As compared with controls, lower 25(OH)D levels were found in participants with current depression (P = 0.001, Cohen's d = 0.21), particularly in those with the most severe symptoms (P = 0.001, Cohen's d = 0.44). In currently depressed persons, 25(OH)D was inversely associated with symptom severity (β = ― 0.19, s.e. = 0.07, P = 0.003) suggesting a dose-response gradient, and with risk (relative risk = 0.90, 95% confidence interval = 0.82―0.99, P = 0.03) of having a depressive disorders at 2-year follow-up. This large cohort study indicates that low levels of 25(OH)D were associated to the presence and severity of depressive disorder suggesting that hypovitaminosis D may represent an underlying biological vulnerability for depression. Future studies should elucidate whether—the highly prevalent—hypovitaminosis D could be cost-effectively treated as part of preventive or treatment interventions for depression.
Titel: |
The association between low vitamin D and depressive disorders
|
---|---|
Autor/in / Beteiligte Person: | MILANESCHI, Y ; HOOGENDIJK, W ; LIPS, P ; HEIJBOER, A. C ; SCHOEVERS, R ; VAN HEMERT, A. M ; BEEKMAN, A. T. F ; SMIT, J. H ; PENNINX, B. W. J. H |
Link: | |
Zeitschrift: | Molecular psychiatry, Jg. 19 (2014), Heft 4, S. 444-451 |
Veröffentlichung: | Basingstoke: Nature Publishing Group, 2014 |
Medientyp: | academicJournal |
Umfang: | print; 8; 57 ref |
ISSN: | 1359-4184 (print) |
Schlagwort: |
|
Sonstiges: |
|