Clinical features of methamphetamine-induced paranoia and preliminary genetic association with DBH-1021C→T in a Thai treatment cohort
In: Addiction (Abingdon. Print), Jg. 109 (2014), Heft 6, S. 965-976
Online
academicJournal
- print; 12; 57 ref
Zugriff:
Aims To explore the clinical features of methamphetamine-induced paranoia (MIP) and associations between MIP and a genetic polymorphism in dopamine β-hydroxylase (DBH-1021C→T). Design Retrospective analysis of clinical presentation and genetic association by χ2 test and logistic regression analysis. Setting A Thai substance abuse treatment center. Participants A total of 727 methamphetamine-dependent (MD) individuals. Measurements Clinical: Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) and the Methamphetamine Experience Questionnaire (MEQ). Genetic: DBH-1021C→T. Findings Forty per cent of individuals (289 of 727; 39.8%) with MD had MIP. Within-binge latency to MIP onset occurred more rapidly in the most recent compared with initial MIP episode (P = 0.02), despite unchanging intake (P = 0.89). Individuals with MIP were significantly less likely to carry lower (TT/CT) compared with higher (CC) activity genotypes (34.3 versus 43.3%: χ21 = 5, P = 0.03). DBH effects were confirmed [odds ratio (OR) = 0.7, P = 0.04] after controlling for associated clinical variables (MD severity, OR = 3.4, P < 0.001: antisocial personality disorder, OR = 2.2, P < 0.001; alcohol dependence, OR = 1.4. P = 0.05; and nicotine dependence, OR = 1.4, P = 0.06). TT/CT carriers were more likely to initiate cigarette smoking (OR = 3.9. P = 0.003) and probably less likely to be dependent on alcohol (OR = 0.6, P = 0.05). Conclusions Among methamphetamine-dependent individuals, paranoia appears to occur increasingly rapidly in the course of a session of methamphetamine use. Severity of methamphetamine dependence and antisocial personality disorder predicts methamphetamine-induced paranoia. The genetic polymorphism in dopamine β-hydroxylase is associated with methamphetamine-induced paranoia and influences smoking initiation.
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Clinical features of methamphetamine-induced paranoia and preliminary genetic association with DBH-1021C→T in a Thai treatment cohort
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Autor/in / Beteiligte Person: | KALAYASIRI, Rasmon ; VERACHAI, Viroj ; GELERNTER, Joel ; MUTIRANGURA, Apiwat ; MALISON, Robert T |
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Zeitschrift: | Addiction (Abingdon. Print), Jg. 109 (2014), Heft 6, S. 965-976 |
Veröffentlichung: | Oxford: Blackwell, 2014 |
Medientyp: | academicJournal |
Umfang: | print; 12; 57 ref |
ISSN: | 0965-2140 (print) |
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