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Drug addiction has been associated with deficits in mesostriatal dopamine (DA) function, but whether this state extends to behavioral addictions such as pathological gambling (PG) is unclear. Here we used positron emission tomography and the D3 receptor-preferring radioligand [11C]-(+)-PHNO during a dual-scan protocol to investigate DA release in response to oral amphetamine in pathological gamblers (n = 12) and healthy controls (n = 11). In contrast with human neuroimaging findings in drug addiction, we report the first evidence that PG is associated with greater DA release in dorsal striatum (54-63% greater [11C]-(+)-PHNO displacement) than controls. Importantly, dopaminergic response to amphetamine in gamblers was positively predicted by D3 receptor levels (measured in substantia nigra), and related to gambling severity, allowing for construction of a mechanistic model that could help explain DA contributions to PG. Our results are consistent with a hyperdopaminergic state in PG, and support the hypothesis that dopaminergic sensitization involving D3-related mechanisms might contribute to the pathophysiology of behavioral addictions.

Titel:	In vivo evidence for greater amphetamine-induced dopamine release in pathological gambling: a positron emission tomography study with [11C]-(+)-PHNO
Autor/in / Beteiligte Person:	BOILEAU, I ; PAYER, D ; CHUGANI, B ; LOBO, D. S. S ; HOULE, S ; WILSON, A. A ; WARSH, J ; KISH, S. J ; ZACK, M
Link:	Full Text Finder (Volltext) http://pascal-francis.inist.fr/vibad/index.php?action=search&terms=28965786
Zeitschrift:	Molecular psychiatry, Jg. 19 (2014), Heft 12, S. 1305-1313
Veröffentlichung:	Basingstoke: Nature Publishing Group, 2014
Medientyp:	academicJournal
Umfang:	print; 9; 75 ref
ISSN:	1359-4184 (print)
Schlagwort:	Catécholamine Catecholamine Catecolamina Dérivé de l'amphétamine Amphetamine derivatives Amfetamina derivado Exploration radioisotopique Radionuclide study Exploración radioisotópica Neurotransmetteur Neurotransmitter Neurotransmisor Trouble du contrôle des impulsions Impulse control disorder Trastorno control impulso Amfétamine Amfetamine Anfetamina Dopamine Dopamina Jeu pathologique Pathological gambling Juego patológico Libération Release Liberación Psychotrope Psychotropic Psicotropo Sensibilisation Sensitization Sensibilización Stimulant SNC CNS stimulant Estimulante SNC Tomographie par émission de positons Positron emission tomography Tomografía emisión positrones Tomoscintigraphie Emission tomography Tomocentelleografía [1C]-(+)-PHNO amphetamine dopamine pathological gambling positron emission tomography sensitization Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Pharmacologie. Traitements medicamenteux Pharmacology. Drug treatments Neuropharmacologie Neuropharmacology Psychoanaleptiques: stimulant snc, antidépresseur, nootrope, normothymique..., (maladie d'alzheimer) Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychopathologie. Psychiatrie Psychopathology. Psychiatry Etude clinique de l'adulte et de l'adolescent Adult and adolescent clinical studies Troubles du comportement social. Comportement criminel. Délinquance Social behavior disorders. Criminal behavior. Delinquency Divers Miscellaneous Psychologie. Psychanalyse. Psychiatrie Psychology. Psychoanalysis. Psychiatry PSYCHOPATHOLOGIE. PSYCHIATRIE Psychopharmacologie Psychopharmacology Psychoanaleptiques: stimulant SNC antidépresseur, nootrope, normothymique… Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer… Biochemistry, molecular biology, biophysics Biochimie, biologie moléculaire, biophysique Cognition Psychology, psychopathology, psychiatry Psychologie, psychopathologie, psychiatrie
Sonstiges:	Nachgewiesen in: FRANCIS Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, ON, Canada ; Vivian M. Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada ; Addictions Program, Centre for Addiction and Mental Health, Toronto, ON, Canada ; Schizophrenia Program, Centre for Addiction and Mental Health, Toronto, ON, Canada ; Department of Psychiatry, University of Toronto, Toronto, ON, Canada ; Campbell Family Mental Health Research Institute, Toronto, ON, Canada ; Department of Pharmacology, University of Toronto, Toronto, ON, Canada ; Clinical Neuroscience Program, Centre for Addiction and Mental Health, Toronto, ON, Canada ; Human Brain Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada ; Department of Public Health Sciences, University of Toronto, Toronto, ON, Canada Rights: Copyright 2015 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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In vivo evidence for greater amphetamine-induced dopamine release in pathological gambling: a positron emission tomography study with [11C]-(+)-PHNO